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CPT Code 45380

Ultimate Guide to CPT Code 45380

For gastroenterology practices, mastering the billing for complex diagnostic procedures is essential. This involves accurately coding for flexible colonoscopies where tissue samples are taken. Navigating the specific guidelines for colonoscopies can significantly impact your practice’s financial well-being.

This ultimate guide offers a roadmap to confidently manage claims related to CPT code 45380. We will explore various clinical scenarios where it applies, discuss the use of modifiers, and explain the billing and reimbursement policies specific to this procedure. 

So, what are you waiting for? Empower your team to overcome billing challenges and streamline your operations.

CPT Code 45380 – Description

CPT code 45380 is from the ‘Endoscopy Procedures on the Rectum’ code range and is maintained by the American Medical Association (AMA). It covers the examination of the colon and rectum using a flexible colonoscope. 

For the unversed, a flexible colonoscope is a tubular instrument with a camera and light source to determine the cause of various symptoms, such as rectal bleeding, abdominal pain, diarrhea, or constipation.

This code also covers the excision (removal) of one or more tissues from suspicious areas using biopsy forceps. The collected specimens are sent to the laboratory for analysis.

Scenarios Where CPT Code 45380 is Applicable

The following are some real-world clinical scenarios where the CPT code 45380 applies:

Chronic Abdominal Pain and Diarrhea

Picture a 48-year-old male patient with intermittent lower abdominal pain and chronic diarrhea for the last six months. The physician ordered some stool studies and blood tests, but the results were inconclusive. Therefore, the provider performs a flexible colonoscopy (CPT code 45380) to investigate the symptoms.

During examination of the descending colon, he observes areas of patchy inflammation and mucosal irregularity. He also takes multiple tissue samples using biopsy forceps and sends them for histopathological analysis.

Persistent Constipation and Abdominal Distension

Imagine a 65-year-old female patient with chronic constipation and persistent abdominal distention for the last 5 months. Dietary changes and laxatives failed to improve the patient’s condition. Thus, the physician performs a flexible colonoscopy (CPT code 45380), suspecting a potential obstruction or motility disorder.

During the examination, he identifies a suspicious, fragile (prone-to-bleeding) tissue area in the ascending colon. He uses biopsy forceps to take multiple specimens for pathological assessment.

Unexplained Rectal Bleeding with Positive FOBT

Consider a 59-year-old female patient with intermittent bright red rectal bleeding for the past 2 weeks. She recently had a positive fecal occult blood test (FOBT). However, she denies experiencing any significant pain or changes in bowel habits. The physician performs a flexible colonoscopy (CPT code 45380) to identify the source of bleeding. 

During the examination, the provider finds a small (5mm) sessile polyp in the sigmoid colon and a few diverticula in the descending colon. He removes the polyps using biopsy forceps and sends the specimen to the lab.

Applicable Modifiers for CPT Code 45380

Discover a few of the applicable modifiers for accurately billing the flexible colonoscopy with biopsy procedure and streamline your revenue cycle:

Modifier PT

What happens when a screening colonoscopy converts into a diagnostic or therapeutic procedure? You append modifier PT to CPT code 45830.

Modifier 33

There may be instances where the physician performs the flexible colonoscopy as a preventive service. When this happens, append modifier 33 to CPT code 45380 to indicate the same to the payer.

Modifier 59

Append modifier 59 to CPT code 45380 when the physician performs a significant, separately identifiable procedure during the same session as a flexible colonoscopy with biopsy.

Use the X{EPSU} modifier if it specifically defines why the flexible colonoscopy is eligible for a separate reimbursement. It is a subset of modifier 59 that offers better coding specificity. Here’s what the modifier X{EPSU} entails:

  • XE – Colonoscopy was performed in a different encounter.
  • XP – A different physician performs the procedure covered under CPT code 45380.
  • XS – Flexible colonoscopy was performed on a different structure.
  • XU – It was an unusual non-overlapping service.

CPT Code 45380 – Billing & Reimbursement Guidelines

Discussed below are the essential billing and reimbursement guidelines related to flexible colonoscopy with biopsy:

Ensure Documentation Completeness

Private and commercial payers will only reimburse the flexible colonoscopy when it is medically necessary. Comprehensive documentation is key to demonstrating the medical necessity of a procedure. Here is what your documentation must include to ensure timely claim processing:

  • Date of service when the physician performs the colonoscopy procedure (CPT code 45380).
  • Patient symptoms and diagnosis that led to this procedure.
  • Maximum depth of scope insertion, e.g., to the cecum.
  • Details about abnormal findings (if any), such as polyps, inflammation, friable areas, etc.
  • Description of the biopsy procedure, i.e., location, method, tissue appearance.

Use Modifiers Appropriately

Many times, payers deny claims because they lack specificity and detail. Modifiers are available to offer better precision for billing. Thus, you should append the relevant modifier with CPT 45380. 

Some common modifiers that apply to flexible colonoscopy with biopsy include 33, 59, X{EPSU}, and PT. You can learn more about their appropriate usage in the ‘Applicable Modifiers for CPT Code 45380’ section.

Note that not every situation demands using modifiers. Overusing or misusing modifiers to bypass bundling edits or to collect higher reimbursements can lead to serious repercussions, such as audits and reputational damage.

Understand Payer-Specific Requirements

Yes, each payer may have specific billing requirements for a flexible colonoscopy with biopsy. Therefore, we recommend familiarizing yourself with the relevant payer’s policies before submitting a claim. Non-compliance with payer policies will result in claim denial, impacting your overall revenue cycle.

Summary

Now, it is time to wrap up. But before bidding adieu, let’s quickly recap everything that we learned in this comprehensive guide. First, we explained the CPT code 45380’s descriptor. It covers a flexible colonoscopy with a biopsy.

Next, we looked into a few clinical scenarios where this CPT code applies. These include unexplained rectal bleeding with positive FOBT, persistent constipation and abdominal distension, and chronic abdominal pain and diarrhea. We also shared a few modifiers that apply to the CPT code 45380, including 33, 59, X{EPSU}, and PT. Finally, we discussed the billing and reimbursement guidelines related to the flexible colonoscopy.

Hopefully, these details will help you overcome challenges related to colonoscopy billing. However, if you still find it difficult, you can partner with professionals at MediBillMD for proven gastroenterology billing services.

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